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Clinical trial confirms GP-prescribed treatments are effective for women with heavy periods


The largest and longest operating medical trial of medical therapies for heavy periods has discovered that women might be tremendously helped by having treatments simply from their GP, with most avoiding hospital operations.


Heavy menstrual bleeding is a standard and debilitating situation which may considerably have an effect on the standard of lifetime of 25 per cent of women aged 18-54. Around a million women search assist for this drawback yearly within the UK and it accounts for 12 per cent of all gynaecology referrals.


The multicentre NIHR-funded randomised managed trial was carried out by researchers on the Universities of Nottingham and Birmingham and Aston University. They adopted the instances of 571 women from 63 common practices throughout the Midlands over a five-year interval. The outcomes are revealed within the British Journal of General Practice.


The women who volunteered have been randomly allotted to obtain both a levonorgestrel Intra Uterine System such because the Mirena coil or generally used oral drugs – corresponding to tranexamic/mefenamic acid or the contraceptive capsule.


The sufferers have been requested to report their menstrual experiences utilizing the Menorrhagia Multi-Attribute Scale. This measures the impact of heavy periods on sensible issues, social life, psychological and bodily health in addition to on work and household life. Other penalties recorded have been surgical intervention, common high quality of life, sexual exercise and security.


After 5 years, each teams had comparable and really vital enchancment within the heaviness of their periods and its impression on their lives. Rates of surgical intervention have been additionally low (80 per cent and 77 per cent didn’t have any surgical procedure reminiscent of endometrial ablation or hysterectomy) with no vital distinction between the coil group and people who took oral drugs.


Leading the trial, GP and Professor of Primary Care, Joe Kai, stated: “This is very encouraging news. Women were badly affected by heavy menstrual bleeding when they entered this trial, with most having problems for over a year beforehand. We know some women may be reluctant to seek help or be unaware that treatment is useful. Others may be put off by the idea of some treatments, such as having a coil, or of needing surgery. This trial shows women can be helped very considerably by treatments from their GP alone, with most avoiding hospital procedures up to five years later. It also shows women starting with either a Mirena coil or other oral medications will have similar benefit over time. This is helpful for women and their GPs to know when first considering what treatments to use, taking account of individual preferences and circumstances. If women troubled by heavy menstrual bleeding do choose to see their GP, we can be confident we can help.”


The researchers are following up the identical women for an extra 5 years – as by then round half could have reached the menopause – to evaluate in the event that they are nonetheless utilizing treatments or have wanted surgical remedy for this drawback.



Article: Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term randomised pragmatic trial in primary care, Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta, British Journal of General Practice, doi: 10.3399/bjgp16X687577, revealed 11 October 2016.


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